Arthritis and Common Chemicals

arthritisMerely because something is hereditary doesn’t mean it has to be inherited unless it’s a defined, overt physical characteristic, such as eye color or hairline. Disease or propensity for disease does not have to telegraph itself through gene expression. In the belief that genetic activity can be turned on and off, more than a handful of scientists are convinced that arthritis, in this case, does not have to pass from seed to seed along the family tree. Arthritis, the osteo- kind, can be spawned from unseen environmental assaults, namely perfluorinated chemicals, which are fluorocarbon derivatives. You remember fluorocarbons. They’re part of the chlorofluorocarbons (CFC’s) once used as propellants in spray cans and in refrigerant fluids. Although they aren’t used for aerosol sprays any more, they’re still in the marketplace. When released into the atmosphere, CFC’s affect stratospheric ozone, the depletion of which is implicated in the rise of skin diseases and climate change, not to mention depressed growth in plants and interrupted photosynthesis. Photosynthesis is important only to those of us who need to eat. Fluorocarbons are bioaccumulative—they are stored in the body.

Of special concern are perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS). (Aren’t abbreviations great?) What in the world are these things used for? If what you own resists stains and water, it probably contains one of these. Ever hear of Scotchgard? How about stone or tile sealers? Got your new sofa treated against kids’ spillage? Fast food wrappers don’t leak grease, do they? Gunk doesn’t stick to dental floss, does it? Ever do any plumbing and use Teflon tape to help seal a joint? Oh, yeah, got Teflon? The oxygen atoms on these chemicals help them to bind proteins to fatty acids or hormone substrates such as albumin, and to nuclear receptors that regulate genes, such as PPAR’s (Anitole, 2007) (Cheng, 2008). Their half-life is about three years. Production of these nifty chemicals has declined for safety reasons, ahem, but exposure remains widespread.

PFOA, especially, is associated with infertility (Fei, 2009) (Joensen, 2009) and ADD/ADHD in young adolescents (Hoffman, 2010). But its association with osteoarthritis concerns us at this time. Fluorine (chemical symbol F) is a corrosive gas that reacts with practically everything else in the periodic table except the noble gases, which happen to be so noble that they don’t mix with anything. If fluorine mixes with something else, it’s now a fluoride. On teeth, from the outside, fluoride is O.K. From inside the body, it’s not. That’s why the toothpaste label says not to swallow it. Fluoride usually enters the body either by inhalation or ingestion. (Did you know that tea contains fluoride? We’ll get to that in a minute.)

F reacts with hydrochloric acid in the stomach to form hydrofluoric acid (HF), which just so happens to be the precursor to Prozac. This acid passes to the liver, but evades phase 1 detoxification, where the liver uses O2 and enzymes to oxidize toxins to make them water-soluble. This short circuit occurs because fluorine is the strongest oxidizer currently known. At this point, hydrofluoric acid passes into the bloodstream and is distributed to all body parts, including bones. Now, bones are made from calcium compounds, particularly carbonated hydroxyapatite. When an acid and a base combine, they form a salt. Hydrofluoric acid mixes with the calcium (alkaline) to form CaF2, an insoluble salt. That increases density of bone, but lowers strength. The bone is less elastic and more prone to fractures. As bone thickens, it restricts mobility. To compound matters, factors that acidify the urine increase the retention of fluoride. However, happily, the opposite is also true. Absorption of fluoride is reduced by calcium (Whitford, 1994).

Tea may pose problems for heavy tea drinkers. Being labeled a heavy tea drinker is not common in the United States unless you earn membership in the gallon-a-day club. Tea plants readily absorb fluoride—and aluminum—from soil. Therefore, the beverage will contain various levels of fluoride, depending on soil levels. Brewed black tea in the States contains about 3 to 4 parts per million (which is practically identical to milligrams per liter); commercial iced tea has between 1 and 4 (Whyte, 2006) (Whitford, 1994) (Izuora, 2011). The number of skeletal fluorosis reports has grown in recent years, but that has been seen mostly in people who consumed 20 milligrams of fluoride a day for decades. In the mean time, 5 milligrams a day (That would be about a quart a day.) can present preclinical stages of fluorosis, so what has been diagnosed as arthritis may actually be skeletal fluorosis. Though this problem is more extensive in the tea cultures of Asia, it’s still a good idea to drink tea in moderation.

Getting back to PFOA and PFOS, levels in humans vary widely. Certain occupations can increase exposure thousands of times, especially for those working in chemical, metal refining and power plants. Drinking water contaminated with these chemicals contributes to human misery as much as direct exposure. Some American states have ground water that contains either naturally occurring fluoride compounds or the wastes from industrial sources. Ohio and West Virginia are two. In areas such as these, osteoarthritis prevalence exceeds that in other regions. Though a terrible affliction for anyone, women seem to be affected more than men. Cartilage damage and inflammatory responses are part of the spectrum (Uhl, 2013).

If you start to feel aches and pains that are new to you, take a look at what you’re been wearing, where you’ve been, and what you ate and drank. Stain resistant trousers and shirts, high intake of black and green teas, and the wrappers from the fast-food joint might be the cause. (See http://www.bodybio.com/content.aspx?page=Enhancing-the-worst)  Global production of these substances has been on the wane, but leftovers still occupy the environment. Substitute compounds are no doubt in the future, but now we have to be concerned about their long-term effects. Although research is sketchy, iodine, calcium, magnesium and boron are being studied as antidotes to fluoride toxicity (Kao, 2004) (Heard, 2001).

References

Cao J, Bai X, Zhao Y, Liu J, Zhou D, Fang S, Jia M, Wu J.
The relationship of fluorosis and brick tea drinking in Chinese Tibetans.
Environ Health Perspect. 1996 Dec;104(12):1340-3.

Cao J, Zhao Y, Liu J, Xirao R.
[Brick-tea type adult bone fluorosis].
Wei Sheng Yan Jiu. 2003 Mar;32(2):141-3.

Cao J, Zhao Y, Liu J, Xirao R, Danzeng S, Daji D, Yan Y.
Brick tea fluoride as a main source of adult fluorosis.
Food Chem Toxicol. 2003 Apr;41(4):535-42.

Cheng X, Klaassen CD.
Perfluorocarboxylic acids induce cytochrome P450 enzymes in mouse liver through activation of PPAR-alpha and CAR transcription factors.
Toxicol Sci. 2008 Nov;106(1):29-36.

Czerwinski E, Nowak J, Dabrowska D, Skolarczyk A, Kita B, Ksiezyk M.
Bone and joint pathology in fluoride-exposed workers.
Arch Environ Health. 1988 Sep-Oct;43(5):340-3.

Fei C, McLaughlin JK, Lipworth L, Olsen J.
Maternal levels of perfluorinated chemicals and subfecundity
Hum Reprod. 2009 May;24(5):1200-5.

Grandjean P, Thomsen G.
Reversibility of skeletal fluorosis.
Br J Ind Med. 1983 Nov;40(4):456-61.

Hayacibara MF, Queiroz CS, Tabchoury CP, Cury JA.
Fluoride and aluminum in teas and tea-based beverages.
Rev Saude Publica. 2004 Feb;38(1):100-5.

Heard K, Hill RE, Cairns CB, Dart RC.
Calcium neutralizes fluoride bioavailability in a lethal model of fluoride poisoning.
J Toxicol Clin Toxicol. 2001;39(4):349-53.

Hoffman K, Webster TF, Weisskopf MG, Weinberg J, Vieira VM.
Exposure to polyfluoroalkyl chemicals and attention deficit/hyperactivity disorder in U.S. children 12-15 years of age
Environ Health Perspect. 2010 Dec;118(12):1762-7.

Izuora K, Twombly JG, Whitford GM, Demertzis J, Pacifici R, Whyte MP.
Skeletal fluorosis from brewed tea.
J Clin Endocrinol Metab. 2011 Aug;96(8):2318-24.

Joensen UN, Bossi R, Leffers H, Jensen AA, Skakkebaek NE, Jørgensen N.
Do perfluoroalkyl compounds impair human semen quality?
Environ Health Perspect. 2009 Jun;117(6):923-7.

Kao WF, Deng JF, Chiang SC, Heard K, Yen DH, Lu MC, Kuo BI, Kuo CC, Liu TY, Lee CH.
A simple, safe, and efficient way to treat severe fluoride poisoning–oral calcium or magnesium.
J Toxicol Clin Toxicol. 2004;42(1):33-40.

Kavanagh D, Renehan J.
Fluoride in tea–its dental significance: a review.
J Ir Dent Assoc. 1998;44(4):100-5.

Kurland ES, Schulman RC, Zerwekh JE, Reinus WR, Dempster DW, Whyte MP.
Recovery from skeletal fluorosis (an enigmatic, American case).
J Bone Miner Res. 2007 Jan;22(1):163-70.

Lau C, Anitole K, Hodes C, Lai D, Pfahles-Hutchens A, Seed J.
Perfluoroalkyl acids: a review of monitoring and toxicological findings.
Toxicol Sci. 2007 Oct;99(2):366-94.

Luo Rui, Liu Ri-guang1, Ye Chuan, Yu Yan-ni, Guan Zhi-zhong
Total knee arthroplasty for the treatment of knee osteoarthritis caused by endemic skeletal fluorosis
Chinese Journal of Tissue Engineering Research. Feb 26, 2012; 16 (9): 1555-1558

Petrone P, Giordano M, Giustino S, Guarino FM.
Enduring fluoride health hazard for the Vesuvius area population: the case of AD 79 Herculaneum.
PLoS One. 2011;6(6):e21085.

Savas S, Cetin M, Akdoğan M, Heybeli N.
Endemic fluorosis in Turkish patients: relationship with knee osteoarthritis.
Rheumatol Int. 2001 Sep;21(1):30-5.

Howard Thomas
Some Non-essential Aerosol Propellant Uses Finally Banned
Federal Regulations:  43 F. R. 11301 (1978)
http://lawlibrary.unm.edu/nrj/19/1/16_thomas_some.pdf

Sarah A. Uhl, Tamarra James-Todd, and Michelle L. Bell
Association of Osteoarthritis with Perfluorooctanoate and Perfluorooctane Sulfonate in NHANES 2003–2008
Environ Health Perspect. February 14, 2013

Whitford GM.
Intake and metabolism of fluoride.
Adv Dent Res. 1994 Jun;8(1):5-14.

Whitford GM.
Fluoride metabolism and excretion in children.
J Public Health Dent. 1999 Fall;59(4):224-8.

Whyte MP.
Fluoride levels in bottled teas.
Am J Med. 2006 Feb;119(2):189-90.

Wong MH, Fung KF, Carr HP.
Aluminium and fluoride contents of tea, with emphasis on brick tea and their health implications.
Toxicol Lett. 2003 Jan 31;137(1-2):111-20.

Xiangjin Ge, Yuting Jiang, Guohua Tang, Meilie Zhang, Yurong Zhao
Investigations on the Occurrence of Osteoarthritis in Middle-aged and Elderly Persons in Fluorosis Afflicted Regions of Gaomi City with High Fluoride Concentration in Drinking Water
Preventive Medicine Tribune. Volume 12, No. 1;  January 2006:  pp. 57-58 ·57·

*These statements have not been evaluated by the FDA.
These products are not intended to treat, diagnose, cure, or prevent any disease.

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