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Diabetes and Omega-3’s

Diabetes, Omega-3 fatty acids Super FoodsReading, interpreting and understanding scientific literature can be tedious because the authors often find that their previous paper on the subject missed its mark or was completely wrong. Easy to do when you are blazing new trails; however, the caution they go through to cover their tracks oftentimes makes for difficult reading. Luc Djousse and his colleagues at the U of Washington reported in the May 18, 2011 edition of the American Journal of Clinical Nutrition that, “With the use of objective biomarkers, long-chain omega 3 Fatty Acids (FAs) and Alpha-Linolenic Acid (ALA) were not associated with a higher incidence of diabetes. Individuals with the highest concentrations of both types of FAs had lower risk of diabetes.”

Speed reading is absolutely out of place. Omega-3 fatty acids in the body help to control the inflammation process, which is a benefit because the start of the healing process—initiated by the omega-6 arachidonic acid—also involves the possibility of getting carried away with the exercise. Say you have a cut or abrasion. The key activity that ensues is to stop the loss of fluids – save the blood.  It is that process which tells the body to start the healing by sending white blood cells and platelets to the site of the wound and to agglomerate and close the exit door by swelling the tissues, which is also another way of looking at inflammation. To inflame can be life saving. The omega-3’s are then involved in the work of modulating the activity helping to ease the inflammation that comes with the correction process.

Fatty acids, especially those that are long and highly unsaturated, increase cell membrane fluidity and functionality. Fatty acids are essential to membrane activity at the location of hormone receptors. Insulin resistance in adult-onset diabetes is directly associated with fewer membrane enhancing long-chain fatty acids, largely due to impaired function of desaturase and elongase enzymes needed for a healthy membrane. Ruiz-Gutierrez 1993, “We have studied the fatty acid composition of erythrocyte membrane phospholipids in nine Type 1 (insulin-dependent) diabetic patients and nine healthy control subjects. Cell membranes from the diabetic patients showed a marked decrease in the total amount of polyunsaturated fatty acids mainly at the expense of docosahexaenoic acid, DHA, and arachidonic acid C20:4n6”.

Cell membrane abnormalities in lipid content are found to be related to poor metabolic control, which is a characteristic of diabetes. Diet is a very important  factor, and interventions with dietary essential fatty acids (EFAs) in the correct ratio (found to be 4:1, omega-6:omega-3), can make a difference. Decsif  T., 2002, “Reduced availability of long-chain polyunsaturates in diabetic children suggests that an enhanced dietary supply of long-chain polyunsaturates may be beneficial”. Children with diabetes demonstrate a deficit of long-chain fatty acids, so incorporating them into a child’s diet is prudent. An unspoken benefit in the application of EFA’s to diabetes treatment is the decrease in triglyceride levels, themselves striking indicators of the potential for cardiovascular issues and very often appearing in persons with diabetes.

Herein resides the prolonged physiological support of the EFAs. For those who lack the efficient conversion of the omega-3 alpha linolenic acid from plant sources (notably flaxseeds and their oil) to EPA and DHA, fish oil may be a viable alternative. In fact the the FA conversion process with diabetes is almost non-existent, but also common with aging.

For quite some time the essential fatty acids have been misunderstood. Of the types of fatty acids, the omega-3’s have received the most publicity, having been applauded for positive health effects, principally, because over the last century the general population ate little fish and had little or no n-3s in the diet. Unless they were more or less health nuts, few did not have any exposure to omega 3s as in flax, and even if they did their ability to elevate up to EPA and DHA was minimal. Fish oil was the answer but the explosion that ensued caused over-consumption and still does.

Hence the comments of Djousse et al that n-3 FAs did not increase diabetes but if both the omega 6s and the 3 s were added together there was marked improvements. There is an inference that n-3s were of no benefit and needed the balance of both EFAs, which we applaud and so should you. Balance is paramount.

References

Djoussé L, Biggs ML, Lemaitre RN, King IB, Song X, Ix JH, Mukamal KJ, Siscovick DS, Mozaffarian D. Plasma omega-3 fatty acids and incident diabetes in older adults. Am J Clin Nutr. 2011 May 18.

Ruiz-Gutierrez V, Stiefel P, Villar J, García-Donas MA, Acosta D, Carneado J.  Cell membrane fatty acid composition in type 1 (insulin-dependent) diabetic patients: relationship with sodium transport abnormalities and metabolic control.  Diabetologia. 1993 Sep;36(9):850-6.

T. Decsif, H. Minda, R. Hermann, A. Kozári, É. Erhardt, I. Burus, Sz. Molnár and Gy. Soltész  Polyunsaturated fatty acids in plasma and erythrocyte membrane lipids of diabetic children  Prostaglandins, Leukotrienes and Essential Fatty Acids. 67(4); Oct 2002: 203-210

*These statements have not been evaluated by the FDA.
These products are not intended to treat, diagnose, cure, or prevent any disease.

The Remarkable 4:1 Fatty Acid Ratio and The Brain

FA-gearbrainDelving into the subject of the Brain and Essential Fats is a difficult journey, primarily because of how important the topic is and how little we know about how we think. There are 100 billion neurons sitting on top of our shoulders with ~60% of that nerve material made up of fats, saturated and unsaturated fatty acids (PUFAs) (Connor 1990, Chang 2009). Every day some portion of our nibbling finds its way into the neurons of our brain and through some miraculous cellular metabolism directly affects how we think, play, sleep and dream.

All cells have fatty acid membranes protecting the cytosolic life that goes on busily inside our cells day after day. Nerves are no different. Neurons have the same protective membranes with the same fatty acid phospholipid composition, but nerve membranes have a special job, they are endowed with the task of carrying all the signals inside our head and transmitting them to regulate all thought and motion. We can’t blink or think without fatty acids, yet we rarely give a thought about what we throw down. Venturing into the kitchen for sustenance puts us in charge of what goes into our brain, or, we may simply transfer that to McDonald’s or Taco Bell, now they’re in charge. The potential for brain damage is awesome, especially if there are little ones waiting patiently at the table. Since our brains are mostly fatty acids (60%), and essential fats should be in most every bite of food we take, a primer on fats and oils is in order, but, caution, there’s a bit of cell chemistry involved, but only a little bit.

This article has 5 basic subjects 1) Shlomo Yehuda’s groundbreaking discovery of the preferred ratio of omega 6 and omega 3 Essential Fatty Acids (EFAs) 2) Yehuda’s 2005 paper on Test Anxiety with his preferred fatty acid ratio, 3) the over consumption of Fish Oils, 4) a primer on fatty acid technology, 5) Good oils, not-so-good oils and bad oil, which – you might want to read first.

There is extensive research on the topic of “diet” and “brain”. Type those two words into Medline, and you’ll get 15,577 “hits” or research reports. Medline is part of the NIH in Washington that organizes medical studies from universities around the world. However, you’ll draw a blank slate if you believe you will advance your knowledge on how to change your diet so you can think better. The subjects of either diet or brain are well researched, but putting them together doesn’t elevate you, in fact the literature appears to say “we don’t have a clue” (Joint WHO/FAO 2002, FAO Food 2008). We know that the membrane is composed of saturated and unsaturated fatty acids, including the omega 6 and the omega 3s, but until the research of Shlomo Yehuda from Israel in 1993, the medical community did not know, and for the most part, even today, refuses to acknowledge the magnitude of his contribution to the subject.

FA-yehudaThe Breakthrough 4:1 Fatty Acid Ratio
Prior to his ’93 paper, “Modulation of learning, pain thresholds, and thermoregulation in the rat by preparations of free purified a-linolenic and linoleic acids:”, Yehuda and others had proposed that diet had an effect on the fatty acid composition of nerve membranes and even stated that fatty acids could mediate some of the observed changes in learning and behavior (Yehuda 1987, Coscina & Yehuda 1986, Yehuda & Carasso 1987, Yehuda 1989). Even though they had observed “changes in learning” in those prior studies, Yehuda now is more definitive. He clearly states in this study that modulation of learning is achieved using a 4:1 ratio, four parts of omega 6 linoleic acid (LA) and one part of omega 3 a-linolenic acid(ALA). He called it Special Formula 3 (SR-3). ω6 linoleic LA is in most all seeds and nuts such as safflower, sunflower, corn, soybean, cottonseed, canola, etc., while ω3 a-linolenic ALA, is found in flax, hemp, chia, walnut, soybean, etc. The discovery of the optimal dietary ratio of the Essential Fatty Acids (EFAs) was highly significant, since, being essential signifies that we cannot produce them and they must be in our food supply.

Earlier Research leading up to the 4:1
Prior experiments using 14C-labeled fatty acids (for brain tracking) had shown a cellular preferential uptake of omega 3 ALA over ω6 LA in the brain as early as 1973 Dhopeshwarkar , 1973). (ω is the lower case Greek letter omega). Initially they attempted to explain it by focusing on the amount of PUFAs (multiple double bonds) in soybean oil. However, sunflower oil, which contains a higher amount of PUFAs than soybean oil, failed to produce the positive effects of soybean oil (Yehuda & Carasso 1987, Yehuda 1989). Since the oil from soybeans contains more ALA (8-9%) than sunflower (about 0.4%), the benefits for the brain must have come from the increased ω3 a-linolenic. If the higher quantity of EFAs were not the answer, it must be somewhere in the ratio of the 6s and the 3s, the ratio to each other that held the key.

It was earlier recognized that ω6 LA (linoleic Acid) was important for normal health and brain development (Dhopeshwarkar, 1983). ω3 ALA had also been determined to have significant biological effects, now both were classified as EFAs (essential). Also, earlier studies suggested that ALA may be quite different from LA and may even have a biochemically distinct function (Bernsohn 1973).

Although there were a few clinical reports of the deficiency of ALA (Holman 1982, Bjerve 1989, Uauy 1990), a number of experiments in monkeys and rats had shown visual and learning impairment after consuming diets that were deficient in ω3 a-linolenic acid (Neuringer 1988, Bourre 1991, Connor 1991). These studies prompted a surge of interest in the role of ω3 ALA in brain development including the eyes (Bazan 1980,1990, Bourre 1989, Clandenin 1991, Cook 1991, Crawford 1976, Cunnane 1991, Holman 1991, Scott 1989, Simopoulos 1991, Specter 1989, Wainwright 1992, Weigand 1991).

Since ω6 LA is more common in our food supply than ω3 ALA, and ALA is now deemed to be essential, even though ω3 ALA is high in grasses, which is not common in our food supply, the question is, how much of each do we need.

The aim of the Yehuda ‘93 study was to test the basic hypothesis; is the ratio of linoleic acid to a-linolenic acid the key factor in mediating the beneficial effects of PUFAs in the body and especially in the brain? This required a significant amount of research to challenge and record the learning characteristics of small animals in a stress condition.

FA-micetrialsThe Learning Apparatus
The Morris water tank, a circular tank ~43 inches in diameter (110 cm), was filled with water with powdered milk added to make it opaque so that rats swimming in the tank were unable to see the resting platform submerged below water level. Each animal was released facing the wall in one of four predetermined starting points each separated by 90° around the inner perimeter. While the animal was swimming in the tank, it was able to observe the contents of the room. Special care was given to keep things in the room in the same location. They could navigate in the tank only by external cues, by looking around while paddling. Each animal was tested 8 times per day in the tank. The order of the starting points was determined by random selection. To prevent possible effects of a magnetic field, each one was allowed 120 sec. to find the platform, with an interval time of 20 sec. between trials. The maximum duration of the test was 16 minutes. The rats were tested on 3 consecutive days. During this period, the platform was in the same location in the tank. For each of the 24 trials (eight trials x three days), the time to find the platform was recorded. A cutoff criterion, defined as the first successful trial, was used to calculate an index of learning ability (rate of learning).

The research team tested 9 groups of rats with 7 different ratios of LA and ALA –3:1, 3.5:1, 4:1, 4.5:1, 5:1, 5.5: 1, and 6:1. Temperature control (thermoregulation) as well as motor activity, and pain threshold, were tested, food intake and body weight were all recorded. The ratios between 3.5:1 to 5:1 showed significant performance, however, the best of all was the 4:1, (4 parts ω6 linoleic to one part ω3 a-linolenic, 80% LA to 20% ALA (note, there is no omega 3 EPA or DHA, only ω3 ALA). The achievement of identifying the optimum 4:1 ratio was of major significance, and has been repeated by the Yehuda team in additional studies and also by others (Clark 1992, Wainwright 1992, Ristić 2003).

FA-budwig-rudinBudwig and Rudin
Looking back on those early years is important to grasp the significance of Yehuda’s SR-3. At BodyBio we had recently completed a computer software analysis of a Johns Hopkins red blood cell fatty acid analysis (RBCFA) as an analytical service for physicians, which was central for our teaching program of fatty acids and the cell membrane. However, the basis of nutritional treatment was a dietary adjustment using the correct EFA oils according to each individual’s test. ALA had been determined by many others to be the key missing ingredient. Discovering Yehuda’s SR-3 was a major breakthrough, since prior dietary efforts to add in the missing a-linolenic acid (ALA) had been a hit or miss exercise. Both seed oils containing ω6 (LA) or ω3 (ALA) were readily available, however, we knew that focusing on either ALA or LA, by themselves, would not provide benefits primarily from the prior history of both Drs. Johanna Budwig and Donald Rudin. Between 1960 both (Budwig) and through 1980 (Rudin) experimented with flax oil, which has a high ALA content (~55%). For years both used flax oil and both recorded significant improvements for disorders such as Schizophrenia, gastrointestinal, drying skin diseases, mucous colitis (spastic colon, irritable bowel syndrome) and others, including cancer. They both reported remarkable healing results. Rudin, specifically wrote that it could last several months, but was always followed by a complete reversal, requiring stopping the flax oil. Then, several months later, he would try flax oil again on the same patient and it would work again, but only for a while and the on-again off-again cycle would return. One can only imagine their level of frustration. Both were brilliant scientists who had published extensively. Rudin was an MD and a Harvard professor, and Budwig had been nominated for a Nobel Prize seven times.

FA-balanceOil-productBoth had correctly identified ω3 a-linolenic as the missing nutritional ingredient for innumerable disorders that plagued society. The EFA ratio of flax oil is 1 to 3.5, completely opposite to Yehuda’s 4:1. They were using too much ALA. If only they had known of Yehuda’s work, the entire history of fatty acids would be rewritten. We know of this first hand since Donald Rudin was on our BodyBio Board of Advisors and shared his experience with us first hand. Unfortunately, he passed away in 2003. Before his death, Dr. Rudin wrote a letter to the editor of the Lancet, which was published, wherein he described the current fish oil ‘Omega 3 Overdose Syndrome.’

Ongoing Yehuda Research
After ’93, the Yehuda group continued their research with numerous studies using the SR-3 formula on both animals and humans, here are a few examples: 1994 on epileptic seizures with 84% reduction of seizures, 1996 on Alzheimer’s with improvements in mood, cooperation, appetite, sleep, ability to navigate in the home, and short term memory, 1996 on lowering cholesterol with improvements in fluidity, cognition, and neuro-pharmacological effects, 1997 with improved learning and improved neuronal communication, 1998 with in-depth analysis of learning, neuronal membrane composition and increases in brain essential fatty acid levels, 2000 on lowering cholesterol, stress, and improved learning, 2001 mediation of the nervous, endocrine, and immune systems, 2004 on control of induced anorexia and improved myelination, 2004 on seizure management, 2005 on student Test Anxiety (details below), 2007 on sleep deprivation, REM sleep, and cognitive impairment, 2011 on ADHD, currently poorly handled with drugs (check out “Anatomy of an Epidemic” by Robert Whitaker, 2010, a must read for anyone concerned about ADHD and all psychiatric disorders).

My wife, Dr. Patricia Kane, and I, have spent almost two decades teaching Yehuda’s brilliant work (the PK Protocol) to a growing group of doctors and their patients worldwide, which, even though subjective lacking documented research, have witnessed dramatic improvements for individuals especially with neurological disorders. In reviewing Yehuda’s studies for this article, we selected the 2005 paper on Test Anxiety with students, which epitomizes the uniqueness of the 4:1 ratio. Test anxiety can seriously impair academic performance, and the mere anticipation of a critical examination can hinder the ability to study for it. All of us, at one time or another, have experienced “Test Anxiety”. The anxiety experienced before an exam or an interview, or first standing before an audience, or a first date, or beginning an athletic event before a crowd of onlookers, all can induce apprehension and anxiety. It’s a universal malady; you could call it “butterflies”.

FA-anxietyManTest Anxiety 2005
As head professor of advanced psychology at Bar Ilan University, Israel, Yehuda had ample experience for this disorder. He first secured two trained psychologists who identified 126 male students as test anxiety sufferers. The Bar Ilan University Ethics Committee approved the study. Seventy other students from the same classes who did not suffer test anxiety, served as the control group. The study started one month before the examination. No food intake was allowed 30min before taking the sample. Each subject was instructed to take one capsule which contained 225 mg of pure linoleic acid and pure a-linolenic acid in a ratio of 4:1, twice daily in the morning and evening. Thirty-eight students received placebo (mineral oil) and 88 received the special FA mixture.

There’s no easy way to judge the EFA’s examination outcomes, however, there are a number of characteristics that illuminated their benefits. The subjects reported better appetite, improved mood, better ability to concentrate, less fatigue during the day, better sleep and the ability to organize themselves for the test was much improved. No improvement was observed among the placebo group. The non-anxiety group who also took the treatment likewise showed some improvement in ability to concentrate, less fatigue during day and improved quality of sleep. While test anxiety students showed an elevated morning cortisol level, the PUFA treatment reduced the elevated level to normal. It is interesting to note that the control group also showed a reduction in their cortisol level.

Improving cortisol levels (lowering) with the SR-3 mixture had also been reported earlier (Yehuda et al. 1999, Van Duinen et al. 2004). The Anxiety Study started one month before the examination. Morning salivary cortisol samples were collected at 8:00 AM, while the subjects were still at home. No food intake was allowed 30min before taking the sample. Briefly, samples were collected using cotton swabs chewed for 2 min and inserted into a plastic test tube, cooled and later measured by radio immunoassay. Seventy-eight out of the 88 test anxiety students reported that even after the conclusion of the study they no longer experience a state of anxiety.

FA-veggieKidEven though the Test Anxiety study demonstrates the importance of correcting body EFAs though diet, there is a subtle characteristic reviewing the results. The improved studying capability occurs without fanfare. There’s no spontaneous improvement, which suggests a subtle changed mental ability. It now becomes the norm. It’s not easy to wrap your mind around the implications of adding the correct EFAs to the diet. Just one teaspoon of 4:1 oil a day. How difficult is that? We readily add 3-4 times that much oil on our salads, which rarely provide the correct EFAs we need. It is generally something like olive oil, which has little beneficial value. What would that do for our youngsters, not just university students, going to school every day? The whole concept is life-changing, and the cost is literally peanuts. At BodyBio we currently use a mixture of sunflower and flax oils that we combine to deliver a 4:1 ratio. Some of our little ones take 5 – 6 tablespoons a day, and request it. Imagine – they request it. What do they know—or what is their brain telling them they need?

FA-mombabyThe Basic Fatty Acid Dilemna
Part of the difficulty of a better understanding of fats and oils stems from the word itself – fat. Some think instantly of excess weight or of someone they knew who was a bit dull “fathead”. The word “fat” has a bad image. In addition the recent media explosion regarding fish oils has managed to distort the entire fatty acid picture. Anyone interested in their health searching Google for the latest is inundated with the marvelous results of fish oil and omega 3 EPA and DHA. However, reviewing the research of brain benefits for fish oil the results are mixed, there are as many negative results as positive (Holness 2004, Arendash 2007, Church 2010, Rockett 2012), even though fish has long been regarded as brain-food.

The sheer volume of information on fish oil and omega 3 is overwhelming. As you would imagine much of the Googled information originates from producers touting their special fish oil. After so much media hype, the inevitable occurred sweeping everyone into taking fish oil. The general philosophy prevailed, “if one is good, 2 or more is better”. I don’t have to tell you that most go for the “MORE”. Yes – fish oils are important for our health, but, careful, too much of any nutrient can harm, remember Budwig and Rudin. At BodyBio we see the over-expression in their RBCFA test results from Hopkins. The over-expression of fish oil has become endemic. Almost everyone seeking to improve their health has taken too much. The RBCFA Report tells it like it is. Too much omega 3 fish oil suppresses the omega 6s. You now have too much 3s and too little 6s, all of which is correctable, if, you know that you have overindulged. Most don’t know. Most never get an RBCFA Report which could tell them. Should you now rush out and get a FA test? The answer is — not necessarily. That’s a medical decision. If you’ve taken more than one a day, our general suggestion is to stop the fish oils and go back to eating fish, or, stop for 3-6 months and then take just 2-4 capsules per week, which will allow the body’s metabolism time to readjust. However, if you are plagued with a difficult health problem an effort to balance your EFAs scientifically is highly recommended, but would require a consultation with your doctor.

Most everyone associates fish oil with the omega 3s, which they are, but – fatty acid technology needs a bit more explanation. To get “the rest of the story” please read the Two EFA Families.

The Two Essential FA Families and their two levels:
As reported there are two (2) EFA families, omega 6 (ω6) and omega 3 (ω3), with the lower FA level LA and ALA (1st floor) becoming the precursor for the upper FA levels (2nd floor) in both families. The lower ω6 level is linoleic acid (LA), found in most nuts and seeds and high in safflower, sunflower, corn, soybean, *cottonseed, *canola, etc. (*these last two are not recommended, canola is high in erucic acid which is toxic to the membrane, cottonseed is permitted higher pesticides since it is not classed as a food). The 2nd floor ω6s, which all animals can produce initially, however slight, is arachidonic acid (AA), which the media has been attacking for half a century, and which is also totally mistaken. There are also two additional 2nd floor ω6 EFAs, GLA from Primrose oil and DGLA from GLA, both are on the 2nd floor with AA. For this discussion we will disregard GLA and DGLA and confine the 2nd floor omega 6s to AA. The 1st floor ω3 FA is a-linolenic acid (ALA) found in flax, hemp, chia, walnuts, soybeans, canola, etc, which is the precursor for the 2nd floor ω3s, EPA (eicosapentaenoic acid) and DHA (docosapentaenoic acid). Viewing the precursors ALA and LA as living on the 1st floor and AA, EPA and DHA as living on the 2nd, we can begin to unravel the distortion of fish oils and the omega 3s.

Fish oil contains only the 2nd floor EPA and DHA, while eating fish provides all of the membrane FAs that the body needs including ω6 EFAs (Connor 1990). A reverse distortion is quite possible concerning omega 6s. Egg yolk contains a high concentration of AA. Imagine a concentrated capsule of egg yolk with a high AA content, which, I must add, we would welcome for individuals with a low test result of AA. Now picture the media taking off touting “Egg Yolk” and the health benefits of Arachidonic Acid (Payet 2004), which is critical for our health (eggs and animal proteins are a preferred source of AA). However, touting that singular nutrient “Egg Yolk AA”, even though important, would not work any better than it has for fish oil. The end result would be an overdose of AA. Balanced nutrition is the only way to go. The vast majority of the media has been woefully ignorant of the two levels of EFAs in their touting of fish oils, omega 3s, and their tirade against ω6s and inflammation, which, is significantly one sided and beyond the scope of this article*.

FA-fishoil-pillsThe Large Animal FA Dilemma
Humans have very limited ability to take the 1st floor EFAs, LA and ALA, and metabolize them up to the 2nd floor EFAs, DGLA, AA, EPA, and DHA (Singh 2005, Chang 2009). Our cellular production for all the vital 2nd floor fatty acids dramatically declines with age (Uauy 2006). All large animals, which we are, lose the ability to maintain adequate production of 2nd floor EFAs, either ω6 or ω3s. Little guys like mice and gerbils, etc., are capable in producing all the AA, EPA and DHA they need, and they do it from LA and ALA. Their metabolism is much higher and their life span much shorter. They can do it – we can’t. So, in a way, for us, all the FAs on the 2nd floor, of necessity, become Essential. We must add them into our diet (which has been our evolutionary history). As a consequence of the metabolic insufficiency, all large animals including the grazing animals, in ratio to their size, have smaller brains and weaker eyesight, except humans and dolphins (Crawford 1989, 2000). All predators get their 2nd floor EFAs – predominantly AA and DHA, from the internal organs and brains of the grass eaters which have accumulated them over their lifetimes. Predators enjoy the higher EFAs at almost every meal, which directly relates to their superior brains and eyesight. Where do we fit into that evolutionary picture (?), certainly not with the grazers.

As discussed, much of Yehuda’s research was with rats. To an extent, using efficient little animals has added to the confusion regarding our evolution. How come we are we so smart and endowed with a large brain if we are inefficient in metabolizing the important brain fatty acids that would make us smart? Michael Crawford, Imperial College, London, along with David Marsh, clears up the mystery in ‘The Driving Force’. They hypothesized, that we did not evolve on the plains of Africa, we were more aquatic and lived near oceans or lakes where we had access to shell fish, crustaceans, and fish oils, as we continue to do today with modern cooling technology.

Fatty Acid metabolism is generally not a table-talk discussion, even though it is a part of most meals and a vital detail for our health. The health value of the essential omega 6s does not correlate with the media hype of claiming that they are the sole source of inflammation in the body*, or that fish oil and the omega 3s are the panacea. However, fatty acid technical manuals cover the subject of fatty acids and membranes quite accurately, showing the beneficial role of the ω6 PUFAs. Also, the newly discovered 4:1 ratio brings the ω3 ALA PUFAs into a clearer focus.

Yehuda laid the foundation in ‘93 with his seminal paper regarding the ratio between the omegas’. His profound 4:1 ratio of omega 6 LA and omega 3 ALA has given us the basic Essential FA formula to enable us to raise fluidity (Yehuda 1996, 2012, Lu XF 2010) of our highly active membranes, which are endowed with that very task. Now, we are better equipped to send the right signals from the brain to run the entire system, and we can do it throughout our lives. In media vernacular, that’s “News”. Think of it – brain function for a lifetime. Take a walk through any psychiatrist office on the globe today and the mere thought of sending clear intelligent signals simply by changing your diet, takes on a whole new meaning.

Good oils, not-so-good oils and bad oils
However it evolved, the bad image of FATs is with us, even though fatty acids are vital for every cell of the body and brain. To add to the distortion, the medical media has descended on saturated fats as heart destructive, which it is not, yet reversing a 100 year negative concept is probably impossible; however, we may be able to dent it with facts.

  1. article1-LipidMembraneFats and oils come in just 2 varieties, either phospholipids with two fatty acid tails or triglycerides with three FA tails. Phospholipids make up the protective skin of the membranes of our cells, while triglycerides are simply put away for later. Phospholipids are tiny building blocks which automatically assemble into membranes and surround every cell and organelle. They are the beginning of all life on the planet, and they are 70% FAT.
  2. FA-moleculeFatty acids do not make you fat, carbs do. Carbohydrates (excess sugar) are converted into the 3 tailed FAs – triglycerides, which are stored for use later, an important asset to have in case we run out of food, which no one does any more, at least not the ones in our neighborhood. A triglyceride is a fat molecule with 3 (tri) fatty acid chains that finds their way around our middle and is the stored fat we regard as “bad”, however, on a baby it can be quite pleasant.
  3. We generally eat fats at most every meal, even if it’s in a salad with dressing. The EFAs are highly fluid, but the SFAs (saturated FAs) are rigid, they are not fluid. Real butter from a cow is a SFA. Our membranes need the SFAs for substance and form, however, we are able to produce SFAs, they are not essential. Most all seeds and nuts have fluid EFAs that are crushed into oils that go into food manufacturing, most of which are over-processed and become rancid and/or hydrogenated, which covers all supermarket oils on the shelf. The over-processing oils also include processed butter look-a-likes, margarines, butter-type spreads, including your favorite mayonnaise, Hellman’s, Mayo, etc. Vegenaise, in the refrigerated section, is a much better choice for mayonnaise.The runny, liquid oils (safflower, sunflower, soybean, corn, flax, etc.) contain the healthy EFAs and should be cold pressed and organic for your table oils. Suggest keeping them in the frig. SFAs are solid in the body (butter, lard, coconut (less so)) but are still vital for our health. They are plentiful in animal foods (beef, eggs, chicken, fish etc.). We need both, SFAs and EFAs.
  4. FA-oliveoil-bottleWhat we generally do not need are MUFAs, mono-unsaturated FAs. They are the omega 9s, predominantly olive oil. All plants and animals are able to produce ω9 MUFA, which provides some fluidity in the body, but, in reality, ω9s are inconsequential. We don’t need them which includes olive oil. It will not harm you if you use it, but will not be missed if you avoid it. Olive oil has an image of health – and respectability. Placing a bottle of olive oil on the table makes the chef look good, though, in essence, what olive oil actually does is provide an oil with less value when there are really better choices. Olive oil has a nice image, but the EFAs are where the action is for body function, especially the brain. If the EFAs are not on the table where you can eat them, you’re thinking machinery will just make do without — not a good idea. Put the olive oil back on the kitchen counter, you can heat it without concern so use it for cooking.
  5. FA-coconutCoconut oil – now there’s a winner. Coconut oil is fluid in the body, but it’s solid in any spot on the globe that happens to be cool. Coconut is a medium chain fat which is rapidly burned for energy in the mitochondria, which loves those shorter FA chains. They are more easily handled and absorbed. There is no better oil for French fries than coconut. In fact that should be a stable food in every house. Try it, their yummy.
  6. FA-frenchFriesThe bad guys on the block are the fast food fries, they’re everywhere in most every fast food chain. They all use vegetable oils, the EFAs, which should not be heated because of their multiple double bonds. They quickly become rancid, and are turned into hydrogenated fats, trans fats, the worse kind for our health. The Fast Food emporiums all heat the EFA oils over and over again, and, for the most part, this same disregard for oils goes on in every restaurant on the globe making it very difficult to dine out and make good food choices.
  7. Over the last century and continuing today, we have been plagued with disinformation about Fats and Oils and have been the recipients of bad manufacturing processes originating from the oil and food producers with mechanical hydrogenation of the EFAs. This is currently changing and becoming less in the Western countries with the increased knowledge of trans fats. However, this ugly mechanical distortion of oils has yet to reach most of the world.

The information contained in this web site is for educational purposes only and is not intended or implied to be a substitute for professional medical advice. Inclusion here does not imply any endorsement or recommendation.  Always seek the advice of your physician or other qualified medical provider for all medical problems prior to starting any new regiment.

These statements have not been evaluated by the FDA.
These products are not intended to treat, diagnose, cure, or prevent any disease.

Fat Facts on Omega 3 and Omega 6 Fatty Acids

Omega-3 fatty acids —EPA and DHA— are the BIG news in nutritional m medicine today — and for some very good reasons. The scientific evidence is now irrefutable that EPA and DHA are essential for good health and long life. They are such important nutrients that agencies and institutions historically hostile to nutrition have gone on record to support their use. The American Medical Association, the American Heart Association, the United States Department of Agriculture (USDA), even the good ol’ “Food and Drug Administration (FDA),” are all praising EPA and DHA.

While all of this is certainly a positive development, the rise in sales of omega 3 (n-3) fatty acid is in direct response to the high press coverage. It’s like everybody on the globe is jumping on the omega 3 fish oil bandwagon. The result of this excessive reporting in the media with relatively little knowledge of fatty acid chemistry, has lead to overindulgence (prescribing and taking too much). TThis overzealous use of omega-3 fish oils has occurred worldwide at a disturbing rate.

At BodyBio we have been observing these results through the in-depth examination of thousands of individual fatty acid tests, year after year. Analyzing red blood cell fatty acids (RBCFAs) is a principal part of what we do at BodyBio. The bioactive ingredients of fish oil, EPA and DHA, are generally found in a ratio of 3 to 2 (180 mg of EPA and 120 of DHA). They are both dynamic and powerful nutrients, with a wide range of functions that influence the brain, the sensory organs, synaptic and cardiac activity, and the modulation of arachidonic acid effects in inflammation. All membrane fatty acids are intimately involved in regulating all aspects of the body’s chemistry, including control of each others’ families, the 6s and the 3s. However, excess omega 3s will easily suppress the omega 6s, whereas the reverse does not seem to occur; 6s do not suppress the 3s.

If we follow the popular media mantra, we are led to believe that adding fish oil to the diet will improve our wellbeing by raising the omega 3s and avoiding / lowering the omega 6s. This should be a good thing, since any suppression of omega 6 arachidonic acid would tend to reduce inflammation and lead to a healthier state. However, based on our research and the testing of red cell lipids over the years, we have found the opposite to be true. Dr. Patricia Kane’s own findings concur.

To understand the fatty acid disturbance we see requires a shift in thinking about omega 6 fatty acids and inflammation. While inflammation can be disturbing, in itself it should not be regarded as bad. Aside from the correction that the body undertakes to alleviate the stress that results in inflamed tissues, it is predominantly sending a signal, a message that something is wrong. We certainly want to suppress the disturbance, but the last thing we should be doing is killing the messenger, which is exactly what fish oil does.

More than 80% of the BodyBio red cell fatty acid tests performed yearly* register high omega 3s and low omega 6s. There is a direct correlation with the amount of fish oil consumed and the elevation of EPA and DHA. Associated with the distorted fatty acid analysis is a wide array of disorders, such as fatigue, irritable bowel syndrome, nausea, eczema, headaches, visual disturbance, memory loss, etc.

While we are told that omega 6s are “bad guys,” there is really no such thing. If it is essential, as omega 6s are, and the body spends precious energy to create and maintain it, it is wrong to assume that the metabolic effort is misdirected. Maybe too little or too much — but certainly not bad. Currently, there is no way for humans to survive without omega 6 fatty acids. This includes arachidonic acid (AA), containing 4 double bonds and occupying as much as 14% of the red cell membrane.  Arachidonic acid also boasts the highest concentration of energy in the membrane as the lead regulator of all cellular signaling, and quite possibly of all regulation in the body. As we have recently seen and hereby report the suppression of AA in a large number of individuals by the over-consumption of fish oil has been directly responsible for an unusual increase in physical and mental distress.

Our approach is to remove fish oil from the diet for a time and to encourage a nutrient-dense diet that is low in carbohydrates and rich in omega 6 fats from foods that include egg yolks, evening primrose oil and a blend of cold-pressed safflower and flaxseed oils (BodyBio Balance Oil delivers a 4:1 ratio of linoleic acid to alpha-linolenic acid.).  Together with essential vitamins and minerals, these dietary inclusions help to elevate lower-order EFA saturation levels. The patients, after shifting their diet and supplementation, consistently report that they all improve. In the world of medicine one should never say all, however, we repeat, all patients tend to reverse their negative symptoms by bringing their omega 6s and their omega 3s back in balance.

It is, after all, about balance. Is fish oil bad for you?? Of course not! The error, either by self-medication or by being over prescribed, is an excessive expression of omega 3s which can occur with any drug or nutrient. Also required, and in part because the medical reliance on fatty acid nutrition is quite new, is a new-found respect for the metabolic power of the omega 3s, especially EPA. Without the valuable analysis from the world’s premier fatty acid laboratory, we would never have been able to make this analysis and relay to you how to readjust your patient’s essential fatty acid balance. We would have no reference to do so.

*The vast majority of BodyBio Red Cell tests were performed on individuals who had been seeking medical help for a period of time before consenting to do an Fatty Acid Analysis. Fish oils were commonly employed in their effort to find relief. The 80% referred to above is unusually high but is the result of 1) that narrow select group and 2) the individuals personal reporting of the use of fish oils often over several years. Would this have been the case 20 years ago? Probably not.

CASE HISTORY #1
Annette was determined that she would not follow in her family’s footsteps in regard to her health. To hold off aging and ill health she used 10 capsules daily of fish oil, restricted all meat, eggs and dairy in her diet and limited her intake of all oil except olive oil that she used in her salad and to cook with. After two years of high fish oil intake, Annette noticed that she was developing eczema. Her allergies got much worse and she felt tired all the time. Her moodiness was irritating to others but worst of all she had developed severe difficulties with her ability to think and perform at work. Annette visited a physician specializing in fatty acid therapy and longevity who tested her red cell lipids and found them to be alarmingly unbalanced. Her omega 3 EPA was 1500% high while her omega 6 Arachidonic Acid was 156 % low and her omega 6 Gamma Linolenic Acid was 94% low. Her doctor explained the importance of balance of her fatty acids and set up a targeted nutritional protocol for her. After two weeks of getting on the correct balance of fatty acids Annette felt much better. Her eczema started to clear, her mood stabilized, her energy and alertness returned and she found her work performance normalized. After 6 months of re-balancing Annette’s physician allowed her to begin fish oil with one capsule of Kirunal daily along with wild salmon and sardines, evening primrose, 4:1 omega 6 to omega 3 balanced oil, and eggs / butter in her diet.

CASE HISTORY #2
Jordan is a 3 year old boy with autism. His mother was told by his natural practitioner to give him 4 capsules of fi sh oil daily. After 4 months on fish oil Jordan’s behavior and attention had deteriorated. Testing Jordan’s red cell lipids revealed that he had a gross overdose of omega 3 as EPA and DHA with a deep suppression of the omega 6s. Jordan was then given primrose oil, eggs, butter and safflower oil for a few months and his behavior and attention improved dramatically. In keeping with balance, Jordan was then given 4:1 omega 6 to omega 3 balanced oil, primrose, eggs / butter and one capsule of Kirunal three times weekly to maintain a balance of his essential fatty acids.

CASE HISTORY #3
Adam is an 8 year old boy with Muscular Dystrophy. A health care practitioner prescribed 6 tablespoons of fish oil which he took over an 18 month period. Adam’s parents were deeply concerned with his deteriorating condition and a red cell lipid test was drawn June 2005. Adam’s EPA was grossly elevated (H) at 3888 %, his DHA was also (H) at 312 % and his Arachidonic was deeply suppressed (L) at 356 %. Adam’s EPA was the highest on record with Arachidonic Acid the lowest ever recorded. Adam presented with symptoms of nausea, poor appetite, hypotonia (low muscle tone), poor coordination, severely abnormal gait (walking), with stiff and very slow movement. Interesting to note that Adam’s brain function was good, even elevated, however he could not perform physically. As soon as the fi sh oil was stopped Adam’s appetite increased and his nausea disappeared. He was started on 10 capsules of high potency evening primrose oil daily along with 4 tablespoons of 4 to 1 omega 6 to omega 3 oil. Because of the severe distortion of Adam’s essential fatty acids it will be necessary to retest in 3 months to track the changes. Fatty Acids are normally tested yearly.

Adam’s hypotonia provides a clearer picture of the modulating effect of EPA on Arachidonic. the term modulate is insuffcient to describe the power of EPA considering excess intake. It takes an exaggerated overdose such as Adam’s to paint a vivid picture of the power of fatty acid function. Elevation of EPA can literally block function, not just modulate, thereby impacting all thought and motion. EPA’s effect is similar to the action of NSAIDS blocking Cox I and II, and could be an alternative therapy to those common drugs. A concept anathema to the drug world since the occasional use of EPA would have few negative concerns, however, deep over-expression could be — as with the above case histories. the mode of action of NSAIDS is to specifically block Arachidonic, which it effectively does. EPA accomplishes the same effect, which opens a new focus on EFA metabolism. It also brings the omega 3 fatty acids into sharper focus in relation to drugs and homeostasis, all of which is little understood or appreciated in today’s rush to endorse too much fish oil. A smaller fish oil capsule with a higher EPA content such as Kirunal could be a much better choice to fight inflammation. It’s natural (NSAIDs are drugs) and we all need fish oil, they’re essential – however, as stated above, use carefully.


Note: There is an innate ability to re-acquire a balanced state given a change in lifestyle. The variation in age, gender, and general health are so varied that to make an estimate as to time difficult. Physicians can order a BodyBio Fatty Acid Profile for accurate assessment to determine the right balance of fatty acids needed. (Information on the BodyBio Red Blood Cell FA test for Health Care Providers – please call BodyBio at 888 320 8338 or go to our website at bodybio.com).

The literature is replete with information on the value of omega 3, with little on the value of omega 6. It is much too deep and complicated a subject to address in brief; however, the omega 6 family is by far the predominant fatty acid family, having vast number of management functions throughout the body. The power of EPA, at ~ 0.46% of the red cell compared to ~14% of arachidonic acid, is relegated to modulate and down-regulate arachidonate, thereby refining function and raising performance to a higher level, which it effectively does. A look inside the retina provides an excellent example of the specialization of the two fatty acid families.

There are 100 million photoreceptor cells responsible for sight in each retina. To perform at a high level they require the optimal lipid energy available in the membranes of the outer segment of the cell. Predators such as cats, bears, birds of prey, all carnivorous life in the oceans, and especially primates have a high concentration of DHA, a 22 lipid carbon chain. DHA has the highest number of double bonds [6] within that chain. The more double bonds, the higher the energy value.

In primates, particularly humans, the membrane of the eye contains ~50-55% DHA (the highest in the body, the brain has ~17- 22%). Grazing animals have ample access to the lowest order of omega 3, alpha linolenic (ALA), which begins the n-3 family with 3 double bonds. ALA is high in green leafy vegetation, although the fatty acid content is low. However, grazing animals cannot efficiently metabolize ALA up to DHA. We are also inefficient in this process, however, we are a predator – we can eat fish and get all the DHA we need. Small mammals, such rats are 100% efficient in fatty acid metabolism. The big grass eaters use instead a 22 carbon omega 6, which they metabolize up to 5 double bonds, the maximum number for the n-6s.

There is a dramatic difference in the energy value of a 22 carbon n-6 with 5 double bonds contrasted to a 22 carbon n-3 DHA with 6 double bonds. That difference registers with a significant improvement in eyesight, which gives all predators a leg up in survival. The big cats can watch the herd close u,p whereas the antelopes have to raise their noses high in the air and sniff, hoping to get a sense of what’s out there. That’s a huge advantage. In addition, the higher concentration of DHA in our predator brains translates to higher intelligence since DHA is directly involved with synaptic activity and brain function. However, it does not correlate that an over-expression of DHA will increase brain power in adults, but if the mother does not take in sufficient omega 3 HUFAs (highly unsaturated fatty acids with DHA) during pregnancy or when nursing, the baby’s intellect may not fully develop. The pregnant mother needs generous intakes to nurture her fetus throughout pregnancy. Postpartum depression has in fact, been linked to omega-3 deficiency. The newborn needs it to build and mature all the organs. Older children need the omega-3s to help them function in school and avoid behavioral problems. Parents need them also, perhaps even more so.

The Right Stuff

Getting these vital fatty acids into the body has presented a challenge of purity, itself a concept that encompasses more than a single idea. Acquiring oil from fish is not as simple as getting juice from an orange, where a single earnest squeeze yields results. In juice, there is nothing that needs to be separated, unless pulp is an issue. With fish bodies, there are concerns with removing proteins, environmental insults like heavy metals and micro-organisms, and even ancillary fats that might impede EFA/DHA uptake.

Practically endless discussion has pitted the triglyceride (TG) form of fish oil against the ethyl-ester (EE) form in terms of bioavailability, safety and efficacy. Looking at myriad scientific reviews, we conclude that the differences are minor and inconsequential, unable to be judged as physiologically or clinically significant. So far, it seems that once a steady state of supplementation has been achieved, the biological outcomes are alike. In fact, most CVD-related trials have used the EE form and the National Eye Institute uses it in its AREDS 2 trials (West, 2016) (Ackman, 1992). Clouding the matter is that humans absorb these fats through different routes:  preduodenal, lymphatic via chylomicrons, and the route that uses the portal vein to the liver. Thus, it is difficult to compare results. It is the EE form that has been recommended for standardization (and has been used to manufacture a pharmaceutical fish oil).

BodyBio Kirunal is derived from fish bodies by a process that uses supercritical fluid extraction based on the very low temperatures of solid carbon dioxide. This process provides an oxygen-free media, therein preventing the oxidation and eventual rancidity common to most fish oil products on the market. It further allows extracting selectively low polar lipid compounds, thus avoiding the co-extraction of polar impurities that include inorganic substances, such as heavy metals.

If there be a limitation to supercritical CO2 extraction, it is the increased cost, not only because of the high-pressure equipment, but also because the raw material needs to be freeze dried in order to reduce moisture below 20% and to keep the n-3 fats, the delicate PUFA’s, unaltered. The high level of n-3 fats in supercritical CO2 extraction surpasses all other processes, largely due to low temperatures and a non-oxidant atmosphere. Rarely does the temperature reach 104° F (40 ° C).

There is no detriment to appearance of the oil liberated in this manner, since color, neutral lipid composition and fatty acids profiles are similar. Important are oil acidity, total oxidation value, inclusion of volatile compounds, sensory properties and heavy metals, all of these characters favoring the supercritical CO2 method. Here, fishy off-flavors are eliminated and the potential for a trimethylamine miasma removed.

To BodyBio’s delight, in spite of the high initial investment, refinement costs and downstream processing eventually make the process competitive in that it may likewise be used to make specialty oils, such as nut oils and seed oils.

EPA and DHA are large and spacious n-3 fats, unable to sit next to each other on a single glycerol molecule. Therefore, most fish oils do not contain more than about 30% EPA and DHA. To increase concentration, these fatty acids can be removed by converting them to ethyl esters. Once they are freed, their concentrations are enriched. Supercritical extraction is able to reduce or eliminate cholesterol and contaminants that include the typical environmental insults, such as dioxins, PCB’s, and heavy metals, offering an EPA/DHA content in excess of 60%. Extending the process to feature supercritical fluid chromatography, 90%+ concentrations may be realized.

Molecular distillation, long the darling of the fish oil trade, suffers as much as 350% higher thermal stress than supercritical fluid extraction, and a much lower capability to selectively extract the essential fats desired. Attaining 95% EPA and DHA gives BodyBio Kirunal a triple value in a single capsule.

Fat Facts: Separating Fat From Fiction

Our life blood is in the sources of fatty acids we ingest to nourish our bodies. The media circus makes it difficult to separate the factoidal wheat from the chaff. The internet would have us believe that fish oil is the answer to all of life’s aches, pains and decrepitudes, and that omega-6 (n-6) fatty acids, especially the linoleic acid that is common to seed oils, is the scourge of our well-being. Nothing could be further from the truth.

Here Are The Facts In A Nutshell:

All essential fatty acids are just that – essential. Removing an essential fatty acid from the diet will likely lead to serious medical conditions. The omega-6 fats in the food supply include linoleic, gamma-linolenic and arachidonic acids. Although health enthusiasts now agree that pasture-raised butter and free-range eggs are healthy, they draw the line at seed oils, labeling linoleic acid as especially detrimental to health. However, these purveyors of misinformation have no qualms about pushing the consumption of nuts, which are heavy in monounsaturated fats and shallow in the polyunsaturated omega-6s. The judgment that n-6 fats are unhealthy arose from their capacity to drive inflammation by converting to arachidonic acid (AA), a physiological process actually lacking in efficiency and reliable outcome. Nonetheless, indisputable is that Linoleic acid (LA) is a primary essential fatty acid vital to the mitochondria. Do you see the problem? No one checked the medical facts. Linoleic acid is crucial to health. To settle the dispute, not one medical paper, not even from the most respected lipid researchers, has found LA to be a threat to health at all.

So What Is Bad For The Body?

Toxic fatty acids from heated, overheated and continuously-heated oils are harmful. The greater is their unsaturation, the greater is their toxicity. While there is no doubt that trans-fats are vile, toxic fatty acids are worse. What they exact upon the brain and body is frightening.

Have you ever noticed a health food store chains with prepared food cook in canola oil? They actually fry chicken in canola oil! Canola is a genetically-modified, polyunsaturated oil that creates dangerous aldehydes when heated to cooking temperatures. These formaldehyde cousins eventually embed themselves into our lipid membranes, causing inflammatory responses and a menagerie of diverse problems. Is olive oil any better? A monounsaturated omega-9, it contains oleic acid, a fatty acid whose health benefits are heralded, but whose associated polyphenols display more salubrity by modulating the oxidation of blood lipids, this according to a 2011 report by the European Food Safety Authority. A monumental concern, made public recently, is that olive oil is being diluted as much as 70% with sunflower, canola, walnut and other polyunsaturated fatty acids (PUFAs).  These relatively tasteless adulterants contribute to aldehyde toxicity when heated. Even at two dollars an ounce, first-cold-pressed extra virgin olive oil may be a contaminated fraud. At its finest, (extra virgin) olive oil serves better as an enhancement than as a cooking oil, unless its temperature is carefully monitored, lest its phenolic promises be compromised. It is prudent to avoid cooking with any monounsaturated (avocado, olive) and especially with polyunsaturated oils (grape seed, sesame, canola, safflower, sunflower, corn) due to their PUFA content. It is advisable to cook at moderate temperatures, using coconut oil, animal fats, or butter/ghee. Get back to basics; guess what our grandmothers used?

To our disappointment, a majority of polyunsaturated fats have become hybridized without our knowledge, leaving us with altered products that fail to deliver the health benefits we once enjoyed. What is now high-oleic sunflower or safflower oil is not the same healthful fat we used to know. To compound matters, the food supply has become a nationwide, uncontrolled experiment in culinary and dietary manipulation, offering the spoils to the victorious industry and the spoiled results to the victims. Salad dressings, mayonnaises and assorted fat-related condiments have suffered a similar fate.

If people are destroyed for lack of knowledge, it is doubly so in the realm of fatty acids. To render false information is lying, but to hide information is also a lie. In this regard, we have been deprived of knowing the details of omega-6 pathways, having been told only that omega-6s present with inflammatory compounds as end-products. First, let’s be aware that pre-formed AA, provided by meat and its fat, and by butter and cream leads to the essential series 2 prostaglandins. Albeit pro-inflammatory, these prostaglandins are the lead eicosanoids in the body and are crucial to maintenance of our health. For example, without them there would be no healing of a cut, since white blood cells and platelets would not be beckoned to the scene. Linoleic acid, the mother n-6 fatty acid, is the premier support of cardiolipin and the mitochondria. LA is converted by enzyme activity to gamma-linolenic acid (GLA), dihomo-gamma linolenic acid (DGLA) and eventually to the anti-inflammatory series 1 prostaglandins. 

The second tidbit to which we need attend is the potentially virulent, toxic and inflammatory character of oils exposed to elevated temperatures. The problem does not come from linoleic acid or any other n-6 fat! We have seen microscope images of cell membranes that have been assaulted and battered by these debased and corrupted lipid entities, particularly in the membranes of individuals suffering autoimmune and neurological diseases, where aberrant, renegade lipids have become attached to their DNA, effectively altering gene expression from epigenetic insult. Removal of aldehyde-ridden supermarket oils from the diet is mandatory if optimal health is our goal. Though not top heavy with PUFAs, olive oil is likewise categorized.

Third in the list we find that essential fatty acids (EFAs) appear in echelons of physiological activity. The lower-echelon fats include linoleic acid (from sunflower seeds, high-linoleic safflower oil and high-linoleic acid sunflower oil) along the n-6 branch, and alpha-linolenic acid (from flaxseed oil, chia seeds and walnuts) along the n-3 branch. The higher-order fatty acids include arachidonic acid (from cream, egg yolks, cheeses and meat) along the n-6 branch, and EPA / DHA (from marine sources) along the n-3 branch.

The fourth item of interest tells us that monounsaturated fatty acids (MUFAs) and saturated fatty acids (SFAs) are not essential, meaning that the body can make them from the diet. These fats offer us only calories and gustatory satiety; they are not bioactive lipids. Avocados, olive oil and tree nuts provide MUFAs, while coconut oil and coconut butter, cocoa butter, meat fats, and dairy butter give us SFAs.

The quality of our Life is riveted in the lipids we ingest as they pivotal in the health of the cell membrane and as we have come to understand… the membrane is everything in optimizing our state of health.

Most Important To Avoid To Regain And Stabilize Health:

  • All fried food including French fries unless cooked at home in coconut oil
  • Fast foods, almost all contain heated, toxic oil
  • Commercial foods organic or not, almost all contain heated, toxic oil
  • Hydrogenated vegetable oil, margarine, processed oils
  • Canola oil -often in processed foods / dressing, contains very long chain fatty acids
  • Peanut butter, peanuts, peanut oil, contains very long chain fatty acids
  • Mustard- contains very long chain fatty acids
  • Commercial mayo or salad dressing, use homemade with high linoleic safflower instead
  • Most Olive oil, limited availability of the pure oil, difficult to tell which one is pure
  • Commercial oils, high-oleic hybrid oils, including those labeled organic

Lipids, Oils And Fats You May Be Included In The Diet, But Don’t Contain Bioactive Lipids:

  • Organic coconut oil, useful in cooking
  • Olive oil, caution – limited availability of the pure oil, does not contain bioactive lipids

Lipids, Oils And Fats That Contain EFAs To Include To Optimize Health:

  • Concentrated phospholipids as PC and PE from BodyBio
  • 4:1 omega-6 to omega-3 oil, SR-3, as BodyBio Balance oil
  • High Linoleic, organic, cold pressed Safflower oil (this is imported)
  • Nutiva® Organic Hempseed oil
  • Evening primrose oil, pure cold pressed (not sourced from China)
  • Wild caught, cold water fish
  • Caviar, Anchovies, Sardines from clean waters, not farmed
  • Free range, organic egg yolks
  • Raw, organic seeds-hemp, chia, sunflower, pumpkin, fenugreek, sesame
  • Homemade kefir (cow, goat, sheep, camel)
  • Limited amounts of grass-fed, free-range sources of dairy (cow, goat, sheep, camel) butter, ghee, cream

Alterations to the food supply explain the fifth entry. Where sunflower, safflower and soybean oils once were high in linoleic acid, they now are high in oleic acid, ostensibly making them candidates for the sauté pan, a place where they will still be denigrated and debased, yet a bad thing, although at a slower rate. The damage done to an oil that has been heated and reheated in a fast-food restaurant or local diner is mind-boggling. It’s little wonder that these oils are reclaimed to be used as biofuels in diesel engines. Using them in salad dressing or atop steamed vegetables is one thing, but cooking with them is quite another. No matter the molecular nature, a heated MUFA / PUFA oil is ultimately toxic.

Sixth in our hit parade is the contraindication of marine oils in the treatment of childhood seizure disorders, where administration of such has only exacerbated the condition. Here, the DHA fraction impinges upon the NMDA receptors and stimulates excitation, while the EPA moiety suppresses beta hydroxybutyrate, the primary ketone. Aggravating the matter is that most commercial fish oils are processed using elevated temperatures for extraction, leading to aldehyde formation and degradation of the fatty acids. Thus-damaged fish oils are toxic. On the other hand, wild fish, the ultimate source of marine oils, are not. Salmon, anchovies, sardines and caviar are preferred.

To realize that coconut oil, olive oil, and avocado oil, among a few others, are not essential fatty acids makes number seven in our list. Coconut oil and MCT oil produce ketones quickly, not needing bile to be digested and absorbed. Since coconut does not contain EFAs or MUFAs, it may be used for cooking.

Number eight is worthy of fanfare and flourish. Oils that carry very-long-chain fatty acids are a considerable challenge to the liver and the brain. Because of their size, they dangle outside the mitochondrial membrane, so need peroxisomes to be metabolized, to be burned or beta oxidized. Mustard oil, canola oil, peanut oil and peanut butter are sources.

Knowing the ninth entry introduces us to the bioactive oils that display EFAs and phospholipids crucial to optimal health. In this camp we find Specific-Ratio 3 or SR-3 oil as a prime source of a balanced 4:1 omega-6 / omega-3 ratio, featuring organic, cold-pressed, non-GMO safflower and flaxseed oils as the mother fatty acids. Related bioactive oils are high-linoleic safflower oil, raw organic seeds (sunflower, hemp, pumpkin, chia) and seed creams (soak overnight, blend), Canadian evening primrose oil, wild cold-water fish (especially caviar, anchovies, sardines), free-range eggs (the yolks).